Publications

Treatment of dementia with bosutinib: An open-label study of a tyrosine kinase inhibitor 

Mahdavi, K., Jordan, S., Barrows, H., Pravdic, M., Habelhah, B., Nicodemus, N….Kuhn, T. (2021) Neurology: Clinical Practice

The pursuit of an effective therapeutic intervention for dementia has inspired interest in the class of medications known as tyrosine kinase inhibitors (TKIs) such as bosutinib. 

 

Results support an overall positive outcome after one year of bosutinib. Future studies should explore the relationship between tyrosine kinases and neurodegenerative pathology as well as related avenues of treatment.

Keywords: dementia, Alzheimer's disease, Parkinson's disease, bosutinib, TKI

 

 

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Improved rTMS Efficacy After FMRI Localizes DLPFC Target To Non-Dominant Hemisphere

Iovine, J., Spivak, N., Jordan, S., Mahdavi, K., Duncan, J., Becerra, S...Mamoun, M. (2019) Brain Stimulation

Repetitive transcranial magnetic stimulation (rTMS) to the left DLPFC is used to treat major depressive disorder (MDD). This case report demonstrates the potential efficacy of using a stimulated fMRI scan to determine the precise position of TMS targets in an attempt to improve treatment outcomes

 

During and after the course of 20 sessions, the patient reported a significantly increased mood, mental clarity, cognitive control of reactivity to stressors, and a decrease in ruminative thoughts. Her BDI score decreased considerably and at a two month follow-up, the patient reported continued significant improvement.

 

Keywords: TMS, FMRI, Neuronavigation, Depression

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Focused ultrasound facilitated exosome delivery

to brodmann area 25 in the treatment of

refractory depression

Mahdavi, K., Packham, H., Nicodemus, N., Jordan, S., Iovine, J., Becerra, S....Mamoun, M. (2019) Brain Stimulation

Emerging data demonstrates that depression involves inflammatory processes in the brain. Exosome treatments are thought to have potential anti-inflammatory benefits. This study intended to provide clinical relief for patients with depression by

increasing localized perfusion to Brodmann area 25 (BA25) in combination with intravenous exosome delivery. 

 

This study provides preliminary evidence supporting

 the safety and efficacy of combined exosome and focused ultrasound treatment for patients with MDD.

 

Data also suggests that focused ultrasound may be a method for facilitating localized exosomal delivery

with clinically meaningful results.

Keywords: Depression, Focused Ultrasound, Exosomes 

 

 

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Translating state-of-the-art brain magnetic resonance imaging (MRI) techniques into clinical practice: multimodal MRI differentiates dementia subtypes in a traditional clinical setting

Kuhn, T., Becerra, S., Duncan, J., Spivak, N., Dang, B., Habelhah, B....Jordan, S. (2021) Quantitative Imaging in Medicine & Surgery

This study sought to validate the clinical utility of multimodal magnetic resonance imaging (MRI) techniques in the assessment of neurodegenerative disorders.

Results demonstrate that regional volumetrics, DTI metrics, and ASL successfully differentiated dementia patients from controls with sufficient sensitivity to differentiate dementia subtypes.

Keywords: Magnetic resonance imaging (MRI); neurodegenerative; dementia; Alzheimer’s; Parkinson’s 

 

 

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A Case of COVID- encephalopathy imaged with fMRI and treated with near-infrared light

 Haroon, J., Mahdavi, K, Zielinski, M..., Jordan, S. (2021) Brain Stimulation

The present case study demonstrates a neurocognitive executive dysfunction brought on by a non-severe

case of COVID-19.

 

Following near-infrared light (NIR) treatment directed at the frontal lobes, there was a return

to normal cognitive functioning.

 

NIR light therapy may be a promising

technique for the treatment of cortical hypoperfusion brought on by COVID-19 infection.

Keywords: COVID-19, near-infrared light, MRI

 

 

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Targeted Plasmalogen Supplementation: Effects on Blood Plasmalogens, Oxidative Stress Biomarkers, Cognition, and Mobility in Cognitively Impaired Persons 

Dayan B. Goodenowe, 1 ,* Jonathan Haroon, 2 Mitchel A. Kling, 3 , 4 , 5 Margaret Zielinski, 2 Kennedy Mahdavi, 2 Barshen Habelhah, 2 Leah Shtilkind, 1 and Sheldon Jordan 2

Plasmalogens are a specific type of glycerophospholipid found in especially high levels in neuronal membranes. Decreased blood and brain levels of DHA containing plasmalogens are associated with decreased cognition and neuromuscular function in humans. 

 

We conducted an investigational clinical trial in 22 cognitively impaired persons to evaluate the effects of an escalating oral dosing regimen of DHA-AAG from 900 to 3,600 mg/day over a 4-month period on blood serum plasmalogen and non-plasmalogen phospholipids and oxidative stress biomarkers. 

 

Changes in cognition and mobility were statistically significant. Cognition improved in nine participants, was unchanged in nine, and declined in four. Mobility improved in twelve, was unchanged in five and declined in four participants.

Keywords: dementia, Alzheimer's disease, plasmalogen

 

 

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Treating dissociative PTSD presenting as a functional movement disorder with TMS stimulation targeting the cingulate gyrus

Blades, R., Jordan, S., Becerra, S., Eusebio, B., Heatwole, M., Iovine, J...Kuhn, T. (2019) Neurological Sciences 

A 29-year-old woman presented with head and neck dystonia, as well as functional seizures. The patient was an active

military service member with a history of combat-related trauma.

 

Inhibitory rTMS was prescribed with the anterior cingulate as the primary target, and supplementary motor and premotor cortices as secondary targets. 

 

Thirty-six sessions later, her symptoms were in remission, and she returned to active duty. This case demonstrates the

potential efficacy of fMRIguided rTMS in the treatment of dissociative PTSD.

Keywords: Dissociative PTSD, Anterior cingulate, TMS, Functional movement disorder

 

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